A fluorescent heavy metal indicator
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Phen Green SK diacetate

Item No. 25393

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3',6'-bis(acetyloxy)-2',7'-dichloro-3-oxo-N-1,10-phenanthrolin-5-yl-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxamide
CAS Number
234075-45-7
Synonyms
  • PGSK diacetate
Molecular Formula
C37H21Cl2N3O8
Formula Weight
706.5
Purity
≥85%
Emission
532 nm
Excitation
507 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
CC(OC1=CC2=C(C=C1Cl)C3(C(C=CC(C(NC4=CC(C=CC=N5)=C5C6=C4C=CC=N6)=O)=C7)=C7C(O3)=O)C8=CC(Cl)=C(OC(C)=O)C=C8O2)=O
InChi Code
InChI=1S/C37H21Cl2N3O8/c1-17(43)47-31-15-29-24(13-26(31)38)37(25-14-27(39)32(48-18(2)44)16-30(25)49-29)23-8-7-20(11-22(23)36(46)50-37)35(45)42-28-12-19-5-3-9-40-33(19)34-21(28)6-4-10-41-34/h3-16H,1-2H3,(H,42,45)
InChi Key
INOXUAMBIQQWOK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $358

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    5 mg

    $895

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    Product Description

    Phen green SK (PGSK) diacetate is a fluorescent heavy metal indicator that reacts with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, and Zn2+.1 PGSK diacetate displays excitation/emission maxima of 507/532 nm, respectively, and fluorescence is quenched upon interaction with metal ions. It has been used to quantify iron in isolated rat hepatocytes, characterize metal-ion selectivity of divalent metal-ion transporter 1 (DMT1), and monitor copper transport across P. sativum chloroplast membranes.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Illing, A.C., Shawki, A., Cunningham, C.L., et al. Substrate profile and metal-ion selectivity of human divalent metal-ion transporter-1. The Journal of Biological Chemisty 287(36), 30485-30496 (2012).

    2. Petrat, F., Rauen, U., and de Groot, H. Determination of the chelatable iron pool of isolated rat hepatocytes by digital fluorescence microscopy using the fluorescent probe, phen green SK. Hepatology 29(4), 1171-1179 (1999).

    3. Shingles, R., Wimmers, L.E., and McCarty, R.E. Copper transport across pea thylakoid membranes. Plant Physiol. 125(1), 145-151 (2004).

    Product Citations

    Yong, Y., Yan, L., Wei, J., et al. A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer’s disease by activating GPX4. Theranostics 14(16), 6161-6184 (2024).