An internal standard for the quantification of eletriptan
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rac-Eletriptan-d3 (hydrobromide)

Item No. 25418

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-((1-(methyl-d3)pyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole, monohydrobromide
Molecular Formula
C22H23D3N2O2S • HBr
Formula Weight
466.5
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=S(CCC1=CC=C(NC=C2CC3N(C([2H])([2H])[2H])CCC3)C2=C1)(C4=CC=CC=C4)=O.Br
InChi Code
InChI=1S/C22H26N2O2S.BrH/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20;/h2-4,7-10,14,16,19,23H,5-6,11-13,15H2,1H3;1H/i1D3;
InChi Key
UTINOWOSWSPFLJ-NIIDSAIPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $208

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    1 mg

    $395

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    Product Description

    rac-Eletriptan-d3 is intended for use as an internal standard for the quantification of eletriptan (Item No. 20048) by GC- or LC-MS. Eletriptan is an agonist of the serotonin (5-HT) receptor types 5-HT1B and 5-HT1D.1 It inhibits forskolin-induced cAMP accumulation in and induces vasoconstriction of isolated rabbit common carotid artery rings (pD2s = 7.6 and 4.9, respectively), an effect that can be blocked by the 5-HT1B antagonist SB216641 but not the 5-HT1D antagonist BRL15572. Eletriptan preferentially induces constriction of isolated human cerebral over coronary arteries (EC50s = 15.8 and 1,995 nM, respectively).2 Formulations containing eletriptan have been used in the treatment of migraine headache.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Akin, D., Onaran, H.O., and Gudal, H. Agonist-directed trafficking explaining the difference between response pattern of naratriptan and sumatriptan in rabbit common carotid artery. Br. J. Pharmacol. 136(2), 171-176 (2002).

    2. Edvinsson, L., Uddman, E., Wackenfors, A., et al. Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: Relationship to clinical effect. Clin. Sci. (Lond.) 109(3), 335-342 (2005).