A bacterial metabolite
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Reveromycin B

Item No. 25481

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
butanedioic acid, 1-[(1S,2E,4E)-1-[(2R,5S,7R,8S)-2-butyl-7-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-8-methyl-1,6-dioxaspiro[4.5]dec-2-yl]-5-carboxy-4-methyl-2,4-pentadien-1-yl] ester
CAS Number
144860-68-4
Molecular Formula
C36H52O11
Formula Weight
660.8
Purity
≥98%
Formulation (Request formulation change)
A lyophilisate
SMILES
CC(/C=C/[C@@H]([C@H](/C=C/C(O)=O)C)O)=C\C[C@H]1O[C@@]2(CC[C@@]([C@H](/C=C/C(C)=C/C(O)=O)OC(CCC(O)=O)=O)(CCCC)O2)CC[C@@H]1C
InChi Code
InChI=1S/C36H52O11/c1-6-7-19-35(30(14-10-25(3)23-33(42)43)45-34(44)17-16-32(40)41)21-22-36(47-35)20-18-27(5)29(46-36)13-9-24(2)8-12-28(37)26(4)11-15-31(38)39/h8-12,14-15,23,26-30,37H,6-7,13,16-22H2,1-5H3,(H,38,39)(H,40,41)(H,42,43)/b12-8+,14-10+,15-11+,24-9+,25-23+/t26-,27-,28-,29+,30-,35+,36-/m0/s1
InChi Key
XVFQIVPMOPJEIO-OXVOKJAASA-N
Origin
Bacterium/Streptomyces
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces.1 It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50 = 6 μg/ml) and exhibits pH-dependent antifungal activity against C. albicans (MICs = 15.6 and >500 μg/ml at pH 3.0 and 7.4, respectively). Unlike reveromycin A (Item No. 17458) and reveromycin C (Item No. 23488), reveromycin B does not inhibit proliferation of KB and K562 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takahashi, H., Osada, H., Koshino, H., et al. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. J. Antibiot. (Tokyo) 45(9), 1414-1419 (1992).