A prodrug form of micheliolide
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Pro-drug Form(s)
25402Micheliolide
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Dimethylamino-Micheliolide

Item No. 25499

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,3aS,9R,9aS,9bS)-3-[(dimethylamino)methyl]-3a,4,5,7,8,9,9a,9b-octahydro-9-hydroxy-6,9-dimethyl-azuleno[4,5-b]furan-2(3H)-one
CAS Number
1403357-81-2
Synonyms
  • ACT001
  • DMAMCL
  • Dimethylaminomicheliolide
Molecular Formula
C17H27NO3
Formula Weight
293.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
CC1=C2[C@@]([C@@](O)(C)CC2)([H])[C@]3([H])[C@@]([C@H](CN(C)C)C(O3)=O)([H])CC1
InChi Code
InChI=1S/C17H27NO3/c1-10-5-6-12-13(9-18(3)4)16(19)21-15(12)14-11(10)7-8-17(14,2)20/h12-15,20H,5-9H2,1-4H3/t12-,13-,14-,15-,17+/m0/s1
InChi Key
ZPBIJIIQXPRJSS-WNZSCWOMSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    Product Description

    Dimethylamino-micheliolide (DMAMCL) is a prodrug form of the sesquiterpene lactone micheliolide (Item No. 25402).1 It inhibits migration and invasion of, and vascular formation by, U-118 MG glioma cells when used at a concentration of 10 µM. DMAMCL enhances cell death induced by the DNA-cross-linking agent cisplatin (Item No. 13119) in U-118 MG cells. In vivo, DMAMCL (200 mg/kg) reduces tumor volume and slows the tumor growth rate in a U-118 MG mouse xenograft model when administered in combination with cisplatin. It also prevents proteinuria and renal failure in a db/db mouse model of diabetic nephropathy.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xi, X., Liu, N., Wang, Q., et al. ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma. Cell Death Dis. 10(10), 757 (2019).

    2. Liu, W., Chen, X., Wang, Y., et al. Micheliolide ameliorates diabetic kidney disease by inhibiting Mtdh-mediated renal inflammation in type 2 diabetic db/db mice. Pharmacol. Res. 150, 104506 (2019).