A fluoroquinolone antibiotic
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Balofloxacin

Item No. 25504

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[3-(methylamino)-1-piperidinyl]-4-oxo-3-quinolinecarboxylic acid
CAS Number
127294-70-6
Synonyms
  • Q-35
Molecular Formula
C20H24FN3O4
Formula Weight
389.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 1 mg/ml with warming
λmax
214, 294 nm
SMILES
CNC(C1)CCCN1C2=C(F)C=C(C(C(C(O)=O)=CN3C4CC4)=O)C3=C2OC
InChi Code
InChI=1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27)
InChi Key
MGQLHRYJBWGORO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    1 g

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    5 g

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    10 g

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    Product Description

    Balofloxacin is a fluoroquinolone antibiotic.1 It is active against clinical isolates of a variety of Gram-positive and Gram-negative bacteria in vitro, including K. pneumoniae, H. influenzae, N. gonorrhoeae, P. mirabilis, S. pyogenes, and methicillin-resistant S. aureus (MRSA; MIC50s = 0.025-0.78 μg/ml). Balofloxacin inhibits DNA gyrase from E. coli, P. aeruginosa, and S. aureus (IC50s = 0.47, 11, and 2.5 μg/ml, respectively, in a DNA supercoiling assay). It reduces mortality in mouse models of systemic S. aureus, MRSA, S. pneumoniae, K. pneumoniae, and P. aeruginosa infection (ED50s = 5, 20, 10, 160, and 50.4 mg/kg, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, T., Otsuki, M., and Nishino, T. In vitro antibacterial activity of Q-35, a new fluoroquinolone. Antimicrob. Agents Chemother. 36(8), 1708-1714 (1992).

    2. Iwasaki, H., Miyazaki, S., Tsuji, A., et al. In vitro and in vivo antibacterial activities of Q-35, a novel fluoroquinolone. Chemotherapy 41(2), 100-112 (1995).