A nondepolarizing neuromuscular blocking agent
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Hexamethonium (bromide)

Item No. 25505

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1,N1,N1,N6,N6,N6-hexamethyl-1,6-hexanediaminium, dibromide
CAS Number
55-97-0
Molecular Formula
C12H30N2 • 2Br
Formula Weight
362.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 16 mg/mlEthanol: 33 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]
InChi Code
InChI=1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
InChi Key
FAPSXSAPXXJTOU-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $28

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    10 g

    $50

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    25 g

    $68

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    100 g

    $180

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    Product Description

    Hexamethonium is a peripherally-acting nondepolarizing neuromuscular blocking agent that acts as an antagonist of nicotinic acetylcholine receptors (nAChRs).1,2 It decreases acetylcholine release induced by carbamoylcholine (Item No. 14486) in isolated cat superior cervical ganglion when used at concentrations of 27.4 and 54.8 µg/ml.3 It also decreases mean arterial pressure in unanesthetized rats when administered at a dose of 40 mg/kg.4 Intraventricular administration of hexamethonium (18 ng, i.c.v.) induces signs of nicotine abstinence, including shaking, writhing, and chewing in nicotine-dependent rats.5 Formulations containing hexamethonium were previously used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gosling, J.A., and Lu, T.C. Uptake and distribution of some quaternary ammonium compounds in the central nervous system of the rat. J. Pharmacol. Exp. Ther. 167(1), 56-62 (1969).

    2. Papke, R.L., Wecker, L., and Stitzel, J.A. Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Pharmacol. Exp. Ther. 333(2), 501-518 (2010).

    3. McKinstry, D.N., and Koelle, G.B. Effects of drugs on acetylcholine release from the cat superior cervical ganglion by carbachol and by preganglionic stimulation. J. Pharmacol. Exp. Ther. 157(2), 328-336 (1967).

    4. Nishida, Y., Tandai-Hiruma, M., Kemuriyama, T., et al. Long-term blood pressure control: is there a set-point in the brain? J. Physiol. Sci. 62(3), 147-161 (2012).

    5. Malin, D.H., Lake, J.R., Schopen, C.K., et al. Nicotine abstinence syndrome precipitated by central but not peripheral hexamethonium. Pharmacol. Biochem. Behav. 58(3), 695-699 (1997).