An internal standard for the quantification of meloxicam
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Unlabeled Version(s)
14906Meloxicam
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Meloxicam-d3

Item No. 25508

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-2-(methyl-d3)-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide, 1,1-dioxide
CAS Number
942047-63-4
Molecular Formula
C14H10D3N3O4S2
Formula Weight
354.4
Purity
≥99% deuterated forms (d1-d3)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
O=S1(C2=CC=CC=C2C(O)=C(C(NC3=NC=C(C)S3)=O)N1C([2H])([2H])[2H])=O
InChi Code
InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)/i2D3
InChi Key
ZRVUJXDFFKFLMG-BMSJAHLVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $193

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    1 mg

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    Product Description

    Meloxicam-d3 is intended for use as an internal standard for the quantification of meloxicam (Item No. 14906) by GC- or LC-MS. Meloxicam is a selective inhibitor of COX-2 (IC50s = 11.8 and 143 μM for COX-2 and COX-1, respectively, in an enzyme activity assay) and a non-steroidal anti-inflammatory drug (NSAID).1 Meloxicam (0.03%) reduces croton oil-induced increases in TNF-α and IL-1β mRNA levels and increases IL-10 mRNA levels in cornea in a rabbit model of acute ocular inflammation.2 It inhibits pleural plasma exudation in a carrageenan-induced rat model of pleurisy when administered at a dose of 3 mg/kg.1 In a canine model of unilateral osteoarthritis of the right stifle joint, meloxicam reduces prostaglandin E2 (PGE2) levels in plasma and right stifle joint synovial fluid when administered at a dose of 0.2 mg/kg.3 Formulations containing meloxicam have been used in the treatment of osteoarthritis and rheumatoid arthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ogino, K., Hatanaka, K., Kawamura, M., et al. Evaluation of pharmacological profile of meloxicam as an anti-inflammatory agent, with particular reference to its relative selectivity for cyclooxygenase-2 over cyclooxygenase-1. Pharmacology 55, 44-53 (1997).

    2. Cruz, R., Quintana-Hau, J.D., González, J.R., et al. Effects of an ophthalmic formulation of meloxicam on COX-2 expression, PGE2 release, and cytokine expression in a model of acute ocular inflammation. Br. J. Ophthalmol. 92, 120-125 (2008).

    3. Jones, C.J., Streppa, H.K., Harmon, B.G., et al. In vivo effects of meloxicam and aspirin on blood, gasteric mucosal, and synovial fluid prosanoid synthesis in dogs. Am. J. Vet. Res. 63, 1527-1531 (2002).