An inhibitor of glucocorticoid resistance
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Glucocorticoid Resistance Inhibitor

Item No. 25553

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-cyclopropyl-5-(4-pyridinyl)-2-pyrimidinamine
CAS Number
947018-15-7
Molecular Formula
C12H12N4
Formula Weight
212.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 10 mg/ml
λmax
274 nm
SMILES
NC1=NC(C2CC2)=C(C3=CC=NC=C3)C=N1
InChi Code
InChI=1S/C12H12N4/c13-12-15-7-10(8-3-5-14-6-4-8)11(16-12)9-1-2-9/h3-7,9H,1-2H2,(H2,13,15,16)
InChi Key
PQLYPFZAOUDDHB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $1,053

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    Cayman Chemical
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    Product Description

    Glucocorticoid resistance inhibitor is an inhibitor of glucocorticoid resistance.1 It inhibits cell growth of the T cell acute lymphoblastic leukemia (T-ALL) cell line CUTTL1 when used in combination with dexamethasone (EC50 = 28 µM) and is less effective when used alone (EC50 = 294 µM). Glucocorticoid resistance inhibitor (6.25-50 µM) preferentially inhibits growth of CUTTL1 cells expressing high levels of the glucocorticoid receptor over cells expressing low levels. It upregulates the gene expression and protein levels of the glucocorticoid receptor and induces expression of dexamethasone-regulated genes when used in combination with dexamethasone but not when used alone.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cantley, A.M., Welsch, M., Ambesi-Impiombato, A., et al. Small molecule that reverses dexamethasone resistance in T-cell acute lymphoblastic leukemia (T-ALL). ACS Med. Chem. Lett. 5(7), 754-759 (2014).