An IMP1 inhibitor
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Product Type

Biochemicals

Research Area

Cancer
Transcription Factors

BTYNB IMP1 Inhibitor

Item No. 25623

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(5-bromo-2-thienyl)methylene]amino]-benzamide
CAS Number
304456-62-0
Molecular Formula
C12H9BrN2OS
Formula Weight
309.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(N)C1=CC=CC=C1/N=C/C2=CC=C(Br)S2
InChi Code
InChI=1S/C12H9BrN2OS/c13-11-6-5-8(17-11)7-15-10-4-2-1-3-9(10)12(14)16/h1-7H,(H2,14,16)/b15-7+
InChi Key
OZEADOPONHLEDS-VIZOYTHASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $209

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    10 mg

    $367

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    25 mg

    $783

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    Cayman Chemical
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    Product Description

    BTYNB IMP1 inhibitor is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA).1 It downregulates c-Myc and β-TrCP1 mRNA and reduces IMP1 protein levels in SK-MEL-2 and IGROV-1 cells. BTYNB IMP1 inhibits proliferation of IMP1-positive ES-2, IGROV-1, and SK-MEL-2 cells (IC50s = 2.3, 3.6, and 4.5 μM, respectively) but not IMP1-negative BG-1 and T47D-KBluc cells (IC50s = >50 μM for both). It also inhibits anchorage-independent growth of SK-MEL-2 cells when used at a concentration of 10 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mahapatra, L., Andruska, N., Mao, C., et al. A novel IMP1 inhibitor, BTYNB, targets c-Myc and inhibits melanoma and ovarian cancer cell proliferation. Transl. Oncol. 10(5), 818-827 (2017).