A glucocorticoid with anti-inflammatory activity
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Betamethasone 17-valerate

Item No. 25640

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-fluoro-11β,21-dihydroxy-16β-methyl-17-[(1-oxopentyl)oxy]-pregna-1,4-diene-3,20-dione
CAS Number
2152-44-5
Molecular Formula
C27H37FO6
Formula Weight
476.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): inbsoluble
λmax
240 nm
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@H](C)[C@]4(OC(CCCC)=O)C(CO)=O)=C1
InChi Code
InChI=1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1
InChi Key
SNHRLVCMMWUAJD-SUYDQAKGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $69

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    50 mg

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    100 mg

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    500 mg

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    Product Description

    Betamethasone 17-valerate is a glucocorticoid with anti-inflammatory activity.1,2 It inhibits the binding of the radiolabeled glucocorticoid dexamethasone to human epidermis and mouse skin (IC50s = 5 and 6 nM, respectively).1 Topical application of betamethasone 17-valerate ointment (0.12%) blocks increases in ear weight in a rat model of ear edema induced by croton oil.2 Formulations containing betamethasone 17-valerate have been used in the treatment of corticosteroid-responsive dermatoses of the scalp.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Epstein, E.H., Jr., and Bonifas, J.M. Glucocorticoid receptors of normal human epidermis. J. Invest. Dermatol. 78(2), 144-146 (1982).

    2. Iizuka, Y., Endo, Y., and Misawa, Y. Two simple methods for the evaluation of topically active anti-inflammatory steroidal ointments. Agents Actions 11(3), 254-259 (1981).