An antihistamine
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Buclizine (hydrochloride)

Item No. 25641

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-piperazine, dihydrochloride
CAS Number
129-74-8
Synonyms
  • NSC 25141
Molecular Formula
C28H33ClN2 • 2HCl
Formula Weight
506.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 0.17 mg/mlEthanol: 0.11 mg/ml
λmax
224, 279 nm
SMILES
ClC(C=C1)=CC=C1C(C2=CC=CC=C2)N3CCN(CC4=CC=C(C(C)(C)C)C=C4)CC3.Cl.Cl
InChi Code
InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H
InChi Key
SDBHDSZKNVDKNU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Cayman Chemical
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    Product Description

    Buclizine is an antihistamine.1 It reduces bronchoconstriction and lethality induced by aerosolized histamine in guinea pigs when administered at a dose of 1 mg/kg. Buclizine (40-200 mg/kg) induces gross malformations, including fusion of the tongue to the palate, cleft palate, micrognathia, and micromelia, and bone malformations in rats.2 It also inhibits cancer cell growth by binding to translationally controlled tumor protein (TCTP) and inducing cell differentiation.3 Formulations containing buclizine have been used to treat nausea induced by pregnancy and motion sickness.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schiller, I.W., and Lowell, F.C. Toxicologic and clinical appraisal of buclizine, a new antihistaminic compound. J. Allergy 27(1), 63-67 (1956).

    2. King, C.T., and Howell, J. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am. J. Obstet. Gynecol. 95(1), 109-111 (1966).

    3. Seo, F.J., Fischer, N., and Efferth, T. Role of TCTP for cellular differentiation and cancer therapy. Results Probl. Cell Differ. 64, 263-281 (2017).