Tazobactam

Tazobactam is a β-lactamase inhibitor with greater activity against Ambler class A serine penicillinases and class C cephalosporinases, including TEM-1, SHV-1, and P99 (IC₅₀s = 97, 150, and 8.5 nM, respectively) than class B metallo-β-lactamases and the class D oxacillinase OXA-1 (IC₅₀s = 400,000 and 1,400 nM, respectively).¹ However, it also inhibits the class D oxacillinase OXA-2 (IC₅₀ = 10 nM). Tazobactam, in combination with piperacillin, is active against Gram-positive (MIC₉₀s = 2-128 µg/ml) and Gram-negative bacteria (MIC₉₀s = 4-128 µg/ml).² In a neutropenic mouse model of thigh infection, tazobactam potentiates the activity of ceftolozane against Enterobacteriaceae.³ Formulations containing tazobactam, alone and in combination with piperacillin, have been used in the treatment of β-lacatamase-producing bacteria.

WARNING This product is not for human or veterinary use.

1. Drawz, S.M., and Bonomo, R.A. Three decades of β-lactamase inhibitors. Clin. Microbiol. Rev. 23(1), 160-201 (2010).

2. Jones, R.N., Pfaller, M.A., Fuchs, P.C., et al. Piperacillin/tazobactam (YTR 830) combination. Comparative antimicrobial activity against 5889 recent aerobic clinical isolates and 60 Bacteroides fragilis group strains. Diagn. Microbiol. Infect. Dis. 12(6), 489-494 (1989).

3. Craig, W.A., and Andes, D.R. In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum β-lactamases, in the thighs of neutropenic mice. Antimicrob. Agents Chemother. 57(4), 1577-1582 (2013).