An inhibitor of ABHD11
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Product Type

Small Molecule Modulators
Small Molecule Inhibitors

Research Area

ML-226

Item No. 25681

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2-ethyl-1-piperidinyl)[4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-methanone
CAS Number
2055172-43-3
Molecular Formula
C23H26N4O2
Formula Weight
390.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mLEthanol: 10 mg/mL
λmax
239 nm
SMILES
O=C(N1N=CC(C(C2=CC=CC=C2)(O)C3=CC=CC=C3)=N1)N4C(CC)CCCC4
InChi Code
InChI=1S/C23H26N4O2/c1-2-20-15-9-10-16-26(20)22(28)27-24-17-21(25-27)23(29,18-11-5-3-6-12-18)19-13-7-4-8-14-19/h3-8,11-14,17,20,29H,2,9-10,15-16H2,1H3
InChi Key
DGRUIUDIVFCWMX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    Product Description

    ML-226 is an inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) that inhibits ABHD11 in vitro and in situ (IC50s = 15 and 0.68 nM, respectively).1 It is 100-fold selective for ABHD11 over approximately 20 other serine hydrolases. ML-226 covalently carbamoylates the active site serine of ABHD11. It can be used as an anti-probe for ML-211 (Item No. 17630), an inhibitor of the protein palmitoyl thioesterases lysophospholipase 1 (LYPLA1) and LYPA2.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Adibekian, A., Hsu, K.-L., Speers, A.E., et al. Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): Anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211. Probe Reports from the NIH Molecular Libraries Program (2010).

    2. Adibekian, A., Martin, B.R., Speers, A.E., et al. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program 1 R01 CA132630, 1-42 (2013).