An inhibitor of ABHD11
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Product Categories

Product Type

Biochemicals
Small Molecule Modulators
Small Molecule Inhibitors

Research Area

ML-226

Item No. 25681

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2-ethyl-1-piperidinyl)[4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-methanone
CAS Number
2055172-43-3
Molecular Formula
C23H26N4O2
Formula Weight
390.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLDMSO:PBS(pH 7.2) (1:4): 0.2 mg/mLEthanol: 10 mg/mL
λmax
239 nm
SMILES
O=C(N1N=CC(C(C2=CC=CC=C2)(O)C3=CC=CC=C3)=N1)N4C(CC)CCCC4
InChi Code
InChI=1S/C23H26N4O2/c1-2-20-15-9-10-16-26(20)22(28)27-24-17-21(25-27)23(29,18-11-5-3-6-12-18)19-13-7-4-8-14-19/h3-8,11-14,17,20,29H,2,9-10,15-16H2,1H3
InChi Key
DGRUIUDIVFCWMX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $117

    Add

    5 mg

    $514

    Add

    10 mg

    $909

    Add
    Product Description

    ML-226 is an inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) that inhibits ABHD11 in vitro and in situ (IC50s = 15 and 0.68 nM, respectively).1 It is 100-fold selective for ABHD11 over approximately 20 other serine hydrolases. ML-226 covalently carbamoylates the active site serine of ABHD11. It can be used as an anti-probe for ML-211 (Item No. 17630), an inhibitor of the protein palmitoyl thioesterases lysophospholipase 1 (LYPLA1) and LYPA2.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Adibekian, A., Hsu, K.-L., Speers, A.E., et al. Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): Anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211. Probe Reports from the NIH Molecular Libraries Program (2010).

    2. Adibekian, A., Martin, B.R., Speers, A.E., et al. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program 1 R01 CA132630, 1-42 (2013).