An inhibitor of DAGLβ, DAGLα, and ABHD6
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Isomer(s)
18933KT109
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(R)-KT109

Item No. 25682

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4-[1,1'-biphenyl]-4-yl-1H-1,2,3-triazol-1-yl)[(2R)-2-(phenylmethyl)-1-piperidinyl]-methanone
CAS Number
2055172-60-4
Molecular Formula
C27H26N4O
Formula Weight
422.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/ml
λmax
279 nm
SMILES
O=C(N1N=NC(C2=CC=C(C3=CC=CC=C3)C=C2)=C1)N4[C@@H](CC5=CC=CC=C5)CCCC4
InChi Code
InChI=1S/C27H26N4O/c32-27(30-18-8-7-13-25(30)19-21-9-3-1-4-10-21)31-20-26(28-29-31)24-16-14-23(15-17-24)22-11-5-2-6-12-22/h1-6,9-12,14-17,20,25H,7-8,13,18-19H2/t25-/m1/s1
InChi Key
JKJMWHULJIOKPJ-RUZDIDTESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    (R)-KT109 is the (R) isomer of the diacylglycerol lipase β (DAGLβ) inhibitor KT109 (Item No. 18933).1 (R)-KT109 is an inhibitor of DAGLβ (IC50 = 0.79 nM) and of DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (Item No. 10008650; IC50 = 25.12 nM). It also inhibits α/β-hydrolase domain-containing protein 6 (ABHD6) with an IC50 value of 2.51 nM. (R)-KT109 is more potent at DAGLβ, DAGLα, and ABHD6 than (S)-KT109 (Item No. 25683).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Deng, H., Kooijman, S., van den Nieuwendijk, A.M.C.H., et al. Triazole ureas act as diacylglycerol lipase inhibitors and prevent fasting-induced refeeding. J. Med. Chem. 60(1), 428-440 (2017).