A zwitterionic detergent
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Biochemicals
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LDAO

Item No. 25699

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-1-dodecanamine, N-oxide
CAS Number
1643-20-5
Synonyms
  • Dimethyldodecylamine N-oxide
  • Lauramine Oxide
  • Lauryldimethylamine Oxide
  • N-Lauryldimethylamine N-oxide
Molecular Formula
C14H31NO
Formula Weight
229.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.3 mg/mlDMSO: 0.1 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 0.1 mg/ml
SMILES
CCCCCCCCCCCC[N+](C)([O-])C
InChi Code
InChI=1S/C14H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-15(2,3)16/h4-14H2,1-3H3
InChi Key
SYELZBGXAIXKHU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $40

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    5 g

    $143

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    10 g

    $263

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    25 g

    $609

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    Product Description

    LDAO is a zwitterionic detergent that can be used to solubilize membrane proteins.1 It has a critical micelle concentration (CMC) of 1-2 mM. LDAO has been used to solubilize and extract colicin A from the plasma membrane and for inactivation of enveloped viruses.1,2 It has also been used in combination with 1-decanoyl-rac-glycerol (10MAG) to encapsulate proteins and nucleic acids dissolved in low viscosity fluids.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Metola, A., Bouchet, A.M., Alonso-Mariño, M., et al. Purification and characterization of the colicin A immunity protein in detergent micelles. Biochim. Biophys. Acta Biomembr. 1859(11), 2181-2192 (2017).

    2. Conley, L., Tao, Y., Henry, A., et al. Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation. Biotechnol. Bioeng. 114(4), 813-820 (2017).

    3. Dodevski, I., Nucci, N.V., Valentine, K.G., et al. Optimized reverse micelle surfactant system for high-resolution NMR spectroscopy of encapsulated proteins and nucleic acids dissolved in low viscosity fluids. J. Am. Chem. Soc. 136(9), 3465-3474 (2014).