A zwitterionic surfactant
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Tetradecylphosphocholine

Item No. 25700

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[hydroxy(tetradecyloxy)phosphinyl]oxy]-N,N,N-trimethyl-ethanaminium, inner salt
CAS Number
77733-28-9
Synonyms
  • Fos-choline 14
Molecular Formula
C19H42NO4P
Formula Weight
379.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 25 mg/ml
SMILES
C[N+](C)(C)CCOP(OCCCCCCCCCCCCCC)([O-])=O
InChi Code
InChI=1S/C19H42NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-18-23-25(21,22)24-19-17-20(2,3)4/h5-19H2,1-4H3
InChi Key
BETUMLXGYDBOLV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $134

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    500 mg

    $213

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    1 g

    $293

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    Product Description

    Tetradecylphosphocholine is a zwitterionic surfactant. It has been used in the solubilization and purification of G protein-coupled receptors (GPCRs).1,2 It has also been used as the stationary phase in ion chromatography for the determination of inorganic acids.3 Tetradecylphosphochline has a critical micelle concentration (CMC) of approximately 0.12 mM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cook, B.L., Ernberg, K.E., Chung, H., et al. Study of a synthetic human olfactory receptor 17-4: Expression and purification from an inducible mammalian cell line. PLoS One 3(8), e2920 (2008).

    2. Ren, H., Yu, D., Ge, B., et al. High-level production, solubilization and purification of synthetic human GPCR chemokine receptors CCR5, CCR3, CXCR4, and CX3CR1. PLoS One 4(2), e4509 (2009).

    3. Hu, W., Hasebe, K., Tanaka, K., et al. Determination of inorganic acids by ion chromatography with n-tetradecylphosphocholine (zwitterionic surfactant) as the stationary phase and pure water as the mobile phase. Fresenius J. Anal. Chem. 370(4), 399-402 (2001).