An internal standard for the quantification of vilazodone
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Vilazodone-d8

Item No. 25712

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)benzofuran-2-carboxamide
CAS Number
1794789-93-7
Molecular Formula
C26H19D8N5O2
Formula Weight
449.6
Purity
≥99% deuterated forms (d1-d8)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: 0.32 mg/ml
SMILES
O=C(N)C(O1)=CC2=C1C=CC(N3C([2H])([2H])C([2H])([2H])N(CCCCC4=CNC5=C4C=C(C#N)C=C5)C([2H])([2H])C3([2H])[2H])=C2
InChi Code
InChI=1S/C26H27N5O2/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32)/i9D2,10D2,11D2,12D2
InChi Key
SGEGOXDYSFKCPT-PMCMNDOISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $448

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    Product Description

    Vilazodone-d8 is intended for use as an internal standard for the quantification of vilazodone (Item No. 21547) by GC- or LC-MS. Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50s = 0.2 and 0.5 nM, respectively).1 It increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex when administered intraperitoneally at doses of 1 and 3 mg/kg, respectively. Vilazodone (1 mg/kg, i.p.) decreases immobility in the forced swim test in both rats and mice. Formulations containing vilazodone have been used in the treatment of depression.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Page, M.E., Cryan, J.F., Sullivan, A., et al. Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist. J. Pharmacol. Exp. Ther. 302(3), 1220-1227 (2002).