A muscle relaxant
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Product Categories

Product Type

Biochemicals

Research Area

Neuroscience

Chlormezanone

Item No. 25716

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one, 1,1-dioxide
CAS Number
80-77-3
Synonyms
  • (±)-Chlormezanone
  • NSC 169108
Molecular Formula
C11H12ClNO3S
Formula Weight
273.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlEthanol: 2 mg/mlPBS (pH 7.2): 0.1 mg/ml
λmax
228 nm
SMILES
ClC1=CC=C(C2N(C)C(CCS2(=O)=O)=O)C=C1
InChi Code
InChI=1S/C11H12ClNO3S/c1-13-10(14)6-7-17(15,16)11(13)8-2-4-9(12)5-3-8/h2-5,11H,6-7H2,1H3
InChi Key
WEQAYVWKMWHEJO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 mg

    $41

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    1 g

    $75

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    Product Description

    Chlormezanone is a centrally acting muscle relaxant.1 It induces paralysis in mice, guinea pigs, dogs, cats, and monkeys (EC50s = 133, <200, 100-250, 50, and 50 mg/kg, respectively). Chlormezanone increases ataxia induced by pentobarbital and alcohol in mice and blocks the crossed extensor reflex of the spine without affecting the knee-jerk reflex in cats. It also induces head drop in rabbits.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gesler, R.M., and Coulston, F. Pharmacologic and toxicologic studies of two new centrally acting skeletal muscle relaxants, chlormethazanone and dichlormethazanone. Toxicol. Appl. Pharmacol. 1(2), 168-184 (1959).