A GVIA iPLA2 inhibitor
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(±)-trans-GK563

Item No. 25732

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,4R)-rel-3-(4-phenylbutyl)-4-propyl-2-oxetanone
CAS Number
2351820-19-2
Synonyms
  • GK563
Molecular Formula
C16H22O2
Formula Weight
246.3
Purity
≥94%
Formulation
A 10 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleDMSO: slightly solubleMethanol: slightly soluble
SMILES
O=C1[C@@H](CCCCC2=CC=CC=C2)[C@H](CCC)O1
InChi Code
InChI=1S/C16H22O2/c1-2-8-15-14(16(17)18-15)12-7-6-11-13-9-4-3-5-10-13/h3-5,9-10,14-15H,2,6-8,11-12H2,1H3/t14-,15-/m0/s1
InChi Key
IAYKBJFWLAKGMR-GJZGRUSLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $103

    Add

    5 mg

    $451

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    10 mg

    $794

    Add
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    Product Description

    trans-(±)-GK563 is a potent β-lactone inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (GVIA iPLA2; IC50 = 1 nM).1 It is selective for GVIA iPLA2 over GVIA cPLA2 (IC50 = 22 μM). trans-(±)-GK563 (1 and 10 μM) inhibits apoptosis induced by IL-1β and IFN-γ in INS-1 β-cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dedaki, C., Kokotou, M.G., Mouchlis, V.D., et al. β-Lactones: A novel class of Ca2+-independent phospholipase A2 (group VIA iPLA2) inhibitors with the ability to inhibit β-cell apoptosis. J. Med. Chem. 62(6), 2916-2927 (2019).