An antibiotic
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Gilvocarcin M

Item No. 25762

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(6-deoxy-α-D-galactofuranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one
CAS Number
77879-89-1
Synonyms
  • Antibiotic 1072A
Molecular Formula
C26H26O9
Formula Weight
482.5
Purity
≥95%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: soluble
SMILES
O=C(O1)C2=C(C(OC)=CC(C)=C2)C3=C1C4=C([C@H]5O[C@@]([H])([C@H](O)C)[C@H](O)[C@H]5O)C=CC(O)=C4C(OC)=C3
InChi Code
InChI=1S/C26H26O9/c1-10-7-14-18(16(8-10)32-3)13-9-17(33-4)20-15(28)6-5-12(19(20)24(13)35-26(14)31)25-22(30)21(29)23(34-25)11(2)27/h5-9,11,21-23,25,27-30H,1-4H3/t11-,21-,22-,23+,25-/m1/s1
InChi Key
BYFOTBZTKXSZHH-FUCVEXJHSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $358

    Add

    2.5 mg

    $1,073

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Gilvocarcin M is an antibiotic originally isolated from S. gilvotanareus.1 It is active against S. aureus when used at a concentration of 32 µg/ml.2 Gilvocarcin M inhibits growth of KB cells (IC50 = 0.52 µg/ml) but has no effect on survival in a P388 mouse model of leukemia when used at doses ranging from 25 to 400 mg/kg.3 Gilvocarcin M intercalates into bacteriophage PM2 DNA.4 It is toxic to rats with an intravenous LD50 value of 450 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakano, H., Matsuda, Y., Ito, K., et al. Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. (Tokyo) 34(3), 266-270 (1981).

    2. Balitz, D.M., O'Herron, F.A., Bush, J., et al. Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. J. Antibiot. (Tokyo) 34(12), 1544-1555 (1981).

    3. Morimoto, M., Okubo, S., Tomita, F., et al. Gilvocarcins, new antitumor antibiotics. 3. Antitumor activity. J. Antibiot. (Tokyo) 34(6), 701-707 (1981).

    4. Tomita, F., Takahashi, K.-I., and Tamaoki, T. Gilvocarcins, new antitumor antibiotics. 4. Mode of action. J. Antibiot. (Tokyo) 35(8), 1038-1041 (1982).