A sesquiterpene with diverse biological activities
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trans-Nerolidol

Item No. 25778

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6E)-3,7,11-trimethyl-1,6,10-dodecatrien-3-ol
CAS Number
40716-66-3
Molecular Formula
C15H26O
Formula Weight
222.4
Purity
≥98%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: miscibleDMSO: miscibleEthanol: miscibleEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
243 nm
SMILES
C=CC(O)(C)CC/C=C(C)/CC/C=C(C)/C
InChi Code
InChI=1S/C15H26O/c1-6-15(5,16)12-8-11-14(4)10-7-9-13(2)3/h6,9,11,16H,1,7-8,10,12H2,2-5H3/b14-11+
InChi Key
FQTLCLSUCSAZDY-SDNWHVSQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $30

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    100 mg

    $53

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    250 mg

    $118

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    500 mg

    $205

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    Product Description

    trans-Nerolidol is a sesquiterpene that has been found in various plants, including C. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4 In a disc assay, trans-nerolidol inhibits the growth of S. aureus, B. subtilis, E. coli, and S. cerevisiae with zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.2 It reduces viability of CaCo-2 adenocarcinoma cells with an IC50 value of 28.7 mg/L and reduces production of reactive oxygen species (ROS).3 trans-Nerolidol is insecticidal against A. aegypti larvae with a 24-hour LC50 value of 9 mg/L.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nissen, L., Zatta, A., Stefanini, I., et al. Characterization and antimicrobial activity of essential oils of industrial hemp varieties (Cannabis sativa L.). Fitoterapia 81(5), 413-419 (2010).

    2. Skaltsa, H.D., Lazari, D.M., Mavromati, A.S., et al. Composition and antimicrobial activity of the essential oil of Scutellaria albida ssp. albida from Greece. Planta Med. 66(7), 672-674 (2000).

    3. Ambrož, M., Boušová, I., Skarka, A., et al. The influence of sesquiterpenes from Myrica rubra on the antiproliferative and pro-oxidative effects of doxorubicin and its accumulation in cancer cells. Molecules 20(8), 15343-15358 (2015).

    4. Chantraine, J.-M., Laurent, D., Ballivian, C., et al. Insecticidal activity of essential oils on Aedes aegypti larvae. Phytother. Res. 12(5), 350-354 (1998).