A turn-on fluorescent probe for lipid radicals
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NBD-Pen

Item No. 25806

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2,6-trimethyl-4-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-6-pentyl-1-piperidinyloxy
CAS Number
1955505-54-0
Molecular Formula
C19H28N5O4
Formula Weight
390.5
Purity
≥95% (mixture of isomers)
Emission
530 nm
Excitation
470 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
CC1(C)CC(NC2=CC=C([N+]([O-])=O)C3=NON=C23)CC(C)(CCCCC)N1[O]
InChi Code
InChI=1S/C19H28N5O4/c1-5-6-7-10-19(4)12-13(11-18(2,3)24(19)27)20-14-8-9-15(23(25)26)17-16(14)21-28-22-17/h8-9,13,20H,5-7,10-12H2,1-4H3
InChi Key
VSTUKLJBZYNKPA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $39

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    1 mg

    $74

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    5 mg

    $251

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    Product Description

    NBD-Pen is a turn-on fluorescent probe for lipid radicals.1 Upon reaction with lipid radicals, NBD-pen displays excitation/emission maxima of 470 and 530 nm, respectively. It is selective for lipid radicals over peroxide, oxygen, hypochlorite, and hydroxy radicals in cell-free assays. NBD-Pen has been used in the detection of lipid radicals in in vitro and in vivo models of hepatocellular carcinoma and oxidative disease.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamada, K., Mito, F., Matsuoka, Y., et al. Fluorescence probes to detect lipid-derived radicals. Nat. Chem. Biol. 12(8), 608-613 (2016).

    2. Ishida, Y., Okamoto, Y., Matsuoka, Y., et al. Detection and inhibition of lipid-derived radicals in low-density lipoprotein. Free Radic. Biol. Med. 113, 487-493 (2017).