A DGAT-1 inhibitor
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T-863

Item No. 25807

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-cyclohexaneacetic acid
CAS Number
701232-20-4
Molecular Formula
C22H26N4O3
Formula Weight
394.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: Slightly soluble
λmax
238, 335 nm
SMILES
OC(C[C@@H]1CC[C@@H](C2=CC=C(C3=NC(C(N)=NC=N4)=C4OC3(C)C)C=C2)CC1)=O
InChi Code
InChI=1S/C22H26N4O3/c1-22(2)19(26-18-20(23)24-12-25-21(18)29-22)16-9-7-15(8-10-16)14-5-3-13(4-6-14)11-17(27)28/h7-10,12-14H,3-6,11H2,1-2H3,(H,27,28)(H2,23,24,25)/t13-,14-
InChi Key
FUIYMYNYUHVDPT-HDJSIYSDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

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    10 mg

    $260

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    25 mg

    $596

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    T-863 is a potent inhibitor of diacylglycerol acetyltransferase-1 (DGAT-1; IC50 = 15 nM).1 It is selective for DGAT-1 over DGAT-2 and acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1; IC50s = >10 and 12 μM, respectively). T-863 inhibits triacylglycerol synthesis in HuTu 80 cells (IC50 = 4 nM). In vivo, T-863 (20 mg/kg) reduces plasma triacylglycerol levels, the ratio of triacylglycerols to diacylglycerols, and body weight in a mouse model of diet-induced obesity.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Birch, A.M., Birtles, S., Buckett, L.K., et al. Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor. J. Med. Chem. 52(6), 1558-1568 (2009).