An anticancer agent
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Death
Apoptosis

Oncrasin-1

Item No. 25808

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
CAS Number
75629-57-1
Molecular Formula
C16H12ClNO
Formula Weight
269.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 17 mg/mLDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mLEthanol: 5 mg/mL
λmax
213, 245, 300 nm
SMILES
O=CC1=CN(CC2=CC=C(Cl)C=C2)C3=CC=CC=C31
InChi Code
InChI=1S/C16H12ClNO/c17-14-7-5-12(6-8-14)9-18-10-13(11-19)15-3-1-2-4-16(15)18/h1-8,10-11H,9H2
InChi Key
ZDRQMXCSSAPUMM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $63

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    25 mg

    $130

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    50 mg

    $242

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    100 mg

    $454

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    Cayman Chemical
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    Product Description

    Oncrasin-1 is an anticancer agent that has activity against lung cancer cells expressing constitutively active K-Ras (IC50s = 0.25, 1, 1.58, and 0.11 for H460, H2122, A549, and H2887 cells, respectively).1 It induces nuclear aggregation of atypical protein kinase C (aPKC) PKCι and apoptosis in T29Kt1 and H460 cells. Oncrasin-1 (100 mg/kg per day) reduces tumor volume and increases survival time in an H460 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Guo, W., Wu, S., Liu, J., et al. Identification of a small molecule with synthetic lethality for K-Ras and protein kinase C iota (PKCι). Cancer Res. 68(18), 7403-7408 (2008).