An inhibitor of Wnt and hedgehog signaling
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Porcupine-IN-1

Item No. 25834

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(3-fluoro-2'-methyl[2,4'-bipyridin]-5-yl)methyl]-9H-carbazole-2-carboxamide
CAS Number
2036044-77-4
Synonyms
  • PORCN-IN-1
Molecular Formula
C25H19FN4O
Formula Weight
410.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: slightly soluble
λmax
250, 304 nm
SMILES
CC1=NC=CC(C2=NC=C(CNC(C3=CC(NC4=C5C=CC=C4)=C5C=C3)=O)C=C2F)=C1
InChi Code
InChI=1S/C25H19FN4O/c1-15-10-17(8-9-27-15)24-21(26)11-16(13-28-24)14-29-25(31)18-6-7-20-19-4-2-3-5-22(19)30-23(20)12-18/h2-13,30H,14H2,1H3,(H,29,31)
InChi Key
GOMFFTZBKYVUOE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $83

    Add

    5 mg

    $310

    Add

    10 mg

    $537

    Add

    25 mg

    $1,032

    Add
    Product Description

    Porcupine-IN-1 is an inhibitor of the Wnt and hedgehog signaling pathways (IC50s = 0.5 and 71 nM, respectively, in cell-based reporter assays).1,2 It inhibits secretion of Wnt3A from Wnt3A-transfected HEK293T cells when used at a concentration of 0.1 μM, indicating inhibition of porcupine, an enzyme that catalyzes palmitoylation of Wnt proteins.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, Z., Xu, X., O'Laoi, R., et al. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the “reversed” amide scaffold. Bioorg. Med. Chem. 24(22), 5861-5872 (2016).

    2. Ma, H., Chen, Q., Zhu, F., et al. Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor. Eur. J. Med. Chem. 149, 110-121 (2018).