A TRIF-biased TLR4 agonist
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Lipid A Monophosphoryl from Salmonella minnesota R595

Item No. 25848

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formulation
A lyophilized powder
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
Shipping & Storage Information
Storage
4°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $492

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    Product Description

    Lipid A monophosphoryl from Salmonella minnesota R595 is a non-toxic fragment of lipopolysaccharide (LPS) extracted from wild-type S. minnesota R595 and a TRIF biased toll-like receptor 4 (TLR4) agonist.1 Lipid A monophosphoryl induces T cell clonal expansion and TRIF-dependent production of G-CSF, IL-10, IP-10, and MCP-1 but has no effect on MyD88-dependent production of the inflammatory cytokines IL-1β, IL-6, MIP-1α, and IFN-γ in mice, indicating decreased potential for inflammatory toxicity compared to LPS and use as a non-toxic vaccine adjuvant.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mata-Haro, V., Cekic, C., Martin, M., et al. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science 316(5831), 1628-1632 (2007).