A biphenyl quinolizidine lactone alkaloid
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Lythridine

Item No. 25865

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,4,4a,5,6,9,10-octahydro-10,14-dihydroxy-17,18-dimethoxy-20H-6,20-methano-11,15-metheno-1H,8H-benzo[g]pyrido[2,1-d][1,5]oxaazacyclohexadecin-8-one, stereoisomer
CAS Number
15299-77-1
Synonyms
  • Sinine
Molecular Formula
C26H31NO6
Formula Weight
453.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
λmax
293, 359 nm
SMILES
COC1=CC(C2N3CCCCC3CC4C2)=C(C5=CC(C(O)CC(O4)=O)=CC=C5O)C=C1OC
InChi Code
InChI=1S/C26H31NO6/c1-31-24-12-18-19(13-25(24)32-2)21-11-17(10-16-5-3-4-8-27(16)21)33-26(30)14-23(29)15-6-7-22(28)20(18)9-15/h6-7,9,12-13,16-17,21,23,28-29H,3-5,8,10-11,14H2,1-2H3
InChi Key
AZYBQXPITOLDBL-UHFFFAOYSA-N
Origin
Plant/Fraxinus hubeiensis
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Lythridine is a biphenyl quinolizidine lactone alkaloid originally isolated from Fraxinus sinica that has antimalarial properties.1 It has also been found in H. salicifolia.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, S.-K., Chang, Y.-T., Chuan, T.-K., et al. The antimalarial drug, sinine. Natl. Med. J. China 27, 327-341 (1941).

    2. Kitakima, M., Yanagisawa, T., Tsukahara, M., et al. Biphenyl ether and biphenyl quinolizidine lactone alkaloids from Heimia salicifolia. Tetrahedron 74(4), 441-452 (2018).