An antioxidant
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N-acetyl-L-Cysteine amide

Item No. 25866

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-2-(acetylamino)-3-mercapto-propanamide
CAS Number
38520-57-9
Synonyms
  • N-Acetylcysteine amide
  • NACA
Molecular Formula
C5H10N2O2S
Formula Weight
162.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 30 mg/ml
SMILES
SC[C@H](NC(C)=O)C(N)=O
InChi Code
InChI=1S/C5H10N2O2S/c1-3(8)7-4(2-10)5(6)9/h4,10H,2H2,1H3,(H2,6,9)(H,7,8)/t4-/m0/s1
InChi Key
UJCHIZDEQZMODR-BYPYZUCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $91

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    10 mg

    $160

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    25 mg

    $378

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    50 mg

    $662

    Add
    Product Description

    N-acetyl-L-Cysteine amide (NACA) is an antioxidant.1,2 It is the amide form of N-acetyl-L-cysteine (NAC; Item No. 20261) and has increased cellular membrane and blood-brain barrier permeability compared to NAC. NACA (750 μM) inhibits glutamate-induced cytotoxicity, decreases in intracellular glutathione (GSH) levels, and increases in intracellular reactive oxygen species (ROS) levels in PC12 cells.3 It reduces cortical tissue damage and decreases the distance traveled to the platform in the Morris water maze in a rat model of traumatic brain injury.2 NACA (60 and 120 mg/kg) also inhibits ovalbumin-induced decreases in GSH, increases in nuclear NF-κB p65 and HIF-1α, and increases in IL-4, IL-5, and IL-13 levels in mouse lung tissue.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sunitha, K., Hemshekhar, M., Thushara, R.M., et al. N-Acetylcysteine amide: A derivative to fulfill the promises of N-Acetylcysteine. Free Radic. Res. 47(5), 357-367 (2013).

    2. Pandya, J.D., Readnower, R.D., Patel, S.P., et al. N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI. Exp. Neurol. 257, 106-113 (2014).

    3. Penugonda, S., Mare, S., Goldstein, G., et al. Effects of N-acetylcysteine amide (NACA), a novel thiol antioxidant against glutamate-induced cytotoxicity in neuronal cell line PC12. Brain Res. 1056(2), 132-138 (2005).

    4. Lee, K.S., Kim, S.R., Park, H.S., et al. A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-κB and hypoxia-inducible factor-1α. Exp. Mol. Med. 39(6), 756-768 (2007).