A fluorescently-tagged C12 ceramide
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BODIPY-C12 Ceramide (d18:1/12:0)

Item No. 25997

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(T-4)-[λ-(3,5-dimethyl-2H-pyrrol-2-ylidene-κN)-N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-3,5-dimethyl-1H-pyrrole-2-dodecanamidato-κN1]difluoro-boron
CAS Number
1246355-58-7
Synonyms
  • BODIPY-C12 Ceramide
  • BODIPY-Ceramide (d18:1/12:0)
  • BODIPY-Cer(d18:1/12:0)
  • BODIPY-N-Lauroyl-D-erythro-Sphingosine
  • B12Cer
Molecular Formula
C42H70BF2N3O3
Formula Weight
713.8
Purity
≥98%
Emission
540 nm
Excitation
505 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleMethanol: Slightly Soluble
SMILES
[F][B-]([N]1C2=C(C)C=C1C)([N+](C(C(C)=C3)=C2CCCCCCCCCCC(N[C@H]([C@H](O)/C=C/CCCCCCCCCCCCC)CO)=O)=C3C)[F]
InChi Code
InChI=1S/C42H70BF2N3O3/c1-6-7-8-9-10-11-12-13-14-15-19-22-25-28-39(50)38(32-49)46-40(51)29-26-23-20-17-16-18-21-24-27-37-41-33(2)30-35(4)47(41)43(44,45)48-36(5)31-34(3)42(37)48/h25,28,30-31,38-39,49-50H,6-24,26-27,29,32H2,1-5H3,(H,46,51)/b28-25+/t38-,39+/m0/s1
InChi Key
NGWZKZIJSBUOIZ-BOOOSZIVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Product Description

    BODIPY-C12 Ceramide (B12Cer) is a fluorescently tagged form of C12 ceramide (Item No. 22530) that displays excitation/emission maxima of 505/540 nm, respectively.1 It is formed when acid sphingomyelinase hydrolyzes BODIPY-C12 sphingomyelin in vitro and has been used to quantify acid sphingomyelinase activity in plasma from patients with Niemann-Pick disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. He, X., Chen, F., Dagan, A., et al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal. Biochem. 314(1), 116-120 (2003).