An agonist of PPARδ
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MA-0204

Item No. 26025

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3R-methyl-6-[2-[[5-methyl-2-[4-(trifluoromethoxy)phenyl]-1H-imidazol-1-yl]methyl]phenoxy]-hexanoic acid
CAS Number
2095128-17-7
Molecular Formula
C25H27F3N2O4
Formula Weight
476.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
C[C@@H](CC(O)=O)CCCOC1=CC=CC=C1CN2C(C3=CC=C(OC(F)(F)F)C=C3)=NC=C2C
InChi Code
InChI=1S/C25H27F3N2O4/c1-17(14-23(31)32)6-5-13-33-22-8-4-3-7-20(22)16-30-18(2)15-29-24(30)19-9-11-21(12-10-19)34-25(26,27)28/h3-4,7-12,15,17H,5-6,13-14,16H2,1-2H3,(H,31,32)/t17-/m1/s1
InChi Key
GYNMVDMBFKGCCR-QGZVFWFLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $193

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    5 mg

    $482

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    10 mg

    $770

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    Product Description

    MA-0204 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It selectively induces reporter gene expression in CV-1 cells expressing human PPARδ (EC50 = 0.4 nM) over CV-1 cells expressing human PPARα or PPARγ (EC50s = 6,990 and >10,000 nM, respectively). MA-0204 increases the expression of mRNA encoding angiopoietin-related protein 4 (ANGPTL4), carnitine palmitoyltransferase 1 (CPT1), and pyruvate dehydrogenase kinase 4 (PDHK4) in primary myoblasts from a patient with Duchenne muscular dystrophy (DMD) in a concentration-dependent manner. In vivo, MA-0204 (30 or 100 mg/kg) increases the expression of mRNA encoding Pdhk4 in the skeletal muscle of mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lagu, B., Kluge, A.F., Tozzo, E., et al. Selective PPAR# modulators improve mitochondrial function: Potential treatment for duchenne muscular dystrophy (DMD). ACS Med. Chem. Lett. (2018).