A β-lactam cephalosporin antibiotic
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Cefradine

Item No. 26060

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7R)-7-[[(2R)-2-amino-2-(1,4-cyclohexadien-1-yl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number
38821-53-3
Synonyms
  • SQ 11,436
Molecular Formula
C16H19N3O4S
Formula Weight
349.4
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
λmax
263 nm
SMILES
O=C(N[C@@H]1C(N2[C@]1([H])SCC(C)=C2C(O)=O)=O)[C@H](N)C3=CCC=CC3
InChi Code
InChI=1S/C16H19N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
InChi Key
RDLPVSKMFDYCOR-UEKVPHQBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

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    1 g

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    Cayman Chemical
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    Product Description

    Cefradine is an orally bioavailable β-lactam cephalosporin antibiotic.1 It is active against S. pyogenes, E. coli, K. pneumoniae, and E. cloacae (MICs = 0.04, 9.4, 9.4, and 6.3 μg/ml, respectively). Cefradine is also active against clinical isolates of S. aureus (MICs = 0.8-6 μg/ml) and S. pyogenes (MICs = 0.1-0.4 μg/ml), as well as H. influenzae, E. coli, and K. pneumoniae (MICs = 6.2-12.5 μg/ml).2 It increases survival in mouse models of systemic lethal infection by S. pyogenes, E. coli, K. pneumoniae, or E. cloacae (ED50s = 5, 37, 122, and 50 mg/kg, respectively), as well as by penicillin-susceptible or -resistant strains of S. aureus (ED50s = 18 and 91 mg/kg, respectively).1 Formulations containing cefradine have previously been used in the treatment of respiratory and urinary tract infections, skin infections, and otitis media.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miraglia, G.J., Renz, K.J., and Gadebusch, H.H. Comparison of the chemotherapeutic and pharmacodynamic activities of cephradine, cephalothin, and cephaloridine in mice. Antimicrob. Agents Chemother. 3(2), 270-273 (1973).

    2. Shibl, A.M., and Durgham, S.M. In-vitro evaluation of a new oral cephalosporin, cefroxadine (CGP 9000). J. Chemother. 2(1), 8-10 (1990).