A sesquiterpenoid with anticancer activity
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Dendrobine

Item No. 26067

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2aS,4aS,5R,6S,7R,7aS,7bR)-decahydro-1,7b-dimethyl-6-(1-methylethyl)-7,5-(epoxymethano)-1H-cyclopent[cd]indol-9-one
CAS Number
2115-91-5
Synonyms
  • (–)-Dendrobine
Molecular Formula
C16H25NO2
Formula Weight
263.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: Soluble
SMILES
CN1[C@]2([H])[C@]([H])(OC3=O)[C@@H](C(C)C)[C@@]3([H])[C@@]4([H])[C@]2(C)[C@@](CC4)([H])C1
InChi Code
InChI=1S/C16H25NO2/c1-8(2)11-12-10-6-5-9-7-17(4)14(16(9,10)3)13(11)19-15(12)18/h8-14H,5-7H2,1-4H3/t9-,10+,11+,12-,13-,14-,16+/m1/s1
InChi Key
RYAHJFGVOCZDEI-UFFNCVEVSA-N
Origin
Plant/Dendrobium stem
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

    $456

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    50 mg

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    Product Description

    Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity.1,2 It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 µg/ml.2 It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 µg/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin (Item No. 13119) at 10 µg/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meng, C.-W., He, Y.-L., Peng, C., et al. Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effect. Fitoterapia 121, 206-211 (2017).

    2. Song, T.-H., Chen, X.-X., Lee, C.K.-F., et al. Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivo. Phytomedicine 53, 18-27 (2019).