An antifungal
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Amorolfine (hydrochloride)

Item No. 26077

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,6S)-rel-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine, monohydrochloride
CAS Number
78613-38-4
Synonyms
  • Ro 14-4767/002
Molecular Formula
C21H35NO • HCl
Formula Weight
354.0
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
213, 219, 279, 318 nm
SMILES
CC(CC1=CC=C(C(C)(C)CC)C=C1)CN2C[C@@H](C)O[C@@H](C)C2.Cl
InChi Code
InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+;
InChi Key
XZKWIPVTHGWDCF-KUZYQSSXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Amorolfine is an antifungal.1 It is active against isolates of T. rubrum, T. mentagrophytes, and C. albicans (MIC90s = 4-15, 4-60, and ≤30-500 ng/ml, respectively). It inhibits the growth of T. mentagrophytes and T. rubrum by 33.7 and 38.5%, respectively, in an in vitro bovine hoof model of onychomycosis.2 Amorolfine also decreases the fungal burden in a rabbit model of onychomycosis when used as a 5% nail lacquer.3 Formulations containing amorolfine have been used in the treatment of fungal infections of the toe- or fingernails.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jo Siu, W.J., Tatsumi, Y., Senda, H., et al. Comparison of in vitro antifungal activities of efinaconazole and currently available antifungal agents against a variety of pathogenic fungi associated with onychomycosis. Antimicrob. Agents Chemother. 57(4), 1610-1616 (2013).

    2. Sleven, R., Lanckacker, E., Boulet, G., et al. Development of a novel in vitro onychomycosis model for the evaluation of topical antifungal activity. J. Microbiol. Methods 112, 73-75 (2015).

    3. Shimamura, T., Kubota, N., Nagasaka, S., et al. Establishment of a novel model of onychomycosis in rabbits for evaluation of antifungal agents. Antimicrob. Agents Chemother. 55(7), 3150-3155 (2011).