An inhibitor of PDE3
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Pimobendan

Item No. 26082

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-5-methyl-3(2H)-pyridazinone
CAS Number
74150-27-9
Synonyms
  • UD-CG 115
Molecular Formula
C19H18N4O2
Formula Weight
334.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml
λmax
268, 329 nm
SMILES
CC(C(C1=CC=C(N=C(C2=CC=C(OC)C=C2)N3)C3=C1)=NN4)CC4=O
InChi Code
InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)
InChi Key
GLBJJMFZWDBELO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $60

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    50 mg

    $108

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    100 mg

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    Product Description

    Pimobendan is an inhibitor of phosphodiesterase 3 (PDE3; IC50 = 0.32 μM for guinea pig cardiac enzyme) that is selective for PDE3 over PDE1, PDE2, and PDE4 (IC50s = >30 μM).1 It is also a calcium sensitizer, decreasing the concentration of calcium required for half-maximal contractile force in isolated, skinned porcine ventricular fibers. Pimobendan increases the force of contraction in electrically-stimulated isolated guinea pig papillary muscles with an EC50 value of 6 μM, indicating positive inotropic effects.2 It increases survival time in dogs with congestive heart failure due to myxomatous mitral valve disease when administered in combination with angiotensin-converting enzyme inhibitors and furosemide (Item No. 17273).3 Formulations containing pimobendan have been used in the treatment of heart failure in dogs.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beier, N., Harting, J., Jonas, R., et al. The novel cardiotonic agent EMD 53 998 is a potent "calcium sensitizer". J. Cardiovasc. Pharmacol. 18(1), 17-27 (1991).

    2. Brunkhorst, D., v der Leyen, H., Meyer, W., et al. Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart. Naunyn Schmiedebergs Arch. Pharmacol. 339(5), 575-583 (1989).

    3. Mizuno, M., Yamano, S., Chimura, S., et al. Efficacy of pimobendan on survival and reoccurrence of pulmonary edema in canine congestive heart failure. J. Vet. Med. Sci. 79(1), 29-34 (2017).