A β2-AR agonist
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Ritodrine (hydrochloride)

Item No. 26084

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αS)-rel-4-hydroxy-α-[(1R)-1-[[2-(4-hydroxyphenyl)ethyl]amino]ethyl]-benzenemethanol, monohydrochloride
CAS Number
23239-51-2
Synonyms
  • DU 21220
  • NSC 291565
  • (±)-Ritodrine
Molecular Formula
C17H21NO3 • HCl
Formula Weight
323.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12.5 mg/mL\DMSO: 11 mg/mLEthanol: 10 mg/mLPBS (pH 7.2): 5 mg/mL
λmax
226, 278 nm
SMILES
OC1=CC=C(CCN[C@H](C)[C@@H](O)C2=CC=C(O)C=C2)C=C1.Cl
InChi Code
InChI=1S/C17H21NO3.ClH/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13;/h2-9,12,17-21H,10-11H2,1H3;1H/t12-,17-;/m1./s1
InChi Key
IDLSITKDRVDKRV-JSUROZADSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $36

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    500 mg

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    1 g

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    5 g

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    Product Description

    Ritodrine is an agonist of β2-adrenergic receptors (β2-ARs).1 It induces relaxation of isolated pig detrusor muscle when used at concentrations ranging from 0.001 to 1 μM. Ritodrine (30 μg/ml) reduces electrically-induced isometric tension in myometrial strips isolated from rabbits on day 25 of pregnancy.2 It also suppresses spontaneous motility of and increases concentration of cyclic AMP (cAMP) in isolated pregnant rat uterus.3 Formulations containing ritodrine were previously used to stop premature labor.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Larsen, J.J. α- and β-adrenoceptors in the detrusor muscle and bladder base of the pig and β-adrenoceptors in the detrusor muscle of man. Br. J. Pharmacol. 65(2), 215-222 (1979).

    2. Schulman, H. The comparative actions of uterine inhibiting drugs. Am. J. Obstet. Gynecol. 130(6), 684-688 (1978).

    3. Ikeda, S., and Tamaoki, H. Pharmacological investigation of ritodrine hydrochloride, a beta2-adrenoceptor stimulant. Jpn. J. Pharmacol. 36(4), 477-484 (1984).