An allosteric modulator of muscarinic acetylcholine receptors
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Gallamine (iodide)

Item No. 26086

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2',2''-[1,2,3-benzenetriyltris(oxy)]tris[N,N,N-triethyl]-ethanaminium, triiodide
CAS Number
65-29-2
Molecular Formula
C30H60N3O3 • 3I
Formula Weight
891.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly SolubleMethanol: Slightly SolubleWater: Slightly Soluble
SMILES
CC[N+](CC)(CC)CCOC1=C(OCC[N+](CC)(CC)CC)C(OCC[N+](CC)(CC)CC)=CC=C1.[I-].[I-].[I-]
InChi Code
InChI=1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3
InChi Key
REEUVFCVXKWOFE-UHFFFAOYSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $54

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    1 g

    $85

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    Product Description

    Gallamine is an allosteric modulator of muscarinic acetylcholine receptors.1 It slows the dissociation of the muscarinic antagonist [3H]NMS from M1-M5 muscarinic receptors, with the highest potency for M2 receptors. Gallamine is cardioselective, inhibiting [3H]NMS binding in rat heart tissue homogenates more potently than in other tissues (IC50s = 0.8 and 3-30 µM, respectively).2 Formulations containing gallamine have previously been used as neuromuscular blockers during surgery.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ellis, J., Huyler, J., and Brann, M.R. Allosteric regulation of cloned m1-m5 muscarinic receptor subtypes. Biochem. Pharmacol. 42(10), 1927-1932 (1991).

    2. Stockton, J.M., Birdsall, J.M., Burgen, A.S.V., et al. Modification of the binding properties of muscarinic receptors by gallamine. Mol. Pharmacol. 23(3), 551-557 (1983).