An internal standard for the quantification of 7α-hydroxy-4-cholesten-3-one
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Unlabeled Version(s)
254427α-hydroxy-4-Cholesten-3-one
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7α-hydroxy-4-Cholesten-3-one-d7

Item No. 26100

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7α)-7-hydroxy-cholest-4-en-3-one-25,26,26,26,27,27,27-d7
CAS Number
2260669-17-6
Molecular Formula
C27H37D7O2
Formula Weight
407.7
Purity
≥99% deuterated forms (d1-d7)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly Soluble
SMILES
O=C1CC[C@@]2(C)C(C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=C1
InChi Code
InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1/i1D3,2D3,17D
InChi Key
IOIZWEJGGCZDOL-CTNVFXSSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $662

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    Product Description

    7α-hydroxy-4-Cholesten-3-one-d7 is intended for use as an internal standard for the quantification of 7α-hydroxy-4-cholesten-3-one (Item No. 25442) by GC- or LC-MS. 7α-hydroxy-4-Cholesten-3-one is a metabolite of 7α-hydroxy cholesterol and an intermediate in the biosynthesis of bile acids.1 Plasma levels of 7α-hydroxy-4-cholesten-3-one positively correlate with the rate of bile acid synthesis in humans and are increased in patients following ileal resection.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Russell, D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu. Rev. Biochem. 72, 137-174 (2003).

    2. Axelson, M., Aly, A., and Sjövall, J. Levels of 7α-hydroxy-4-cholesten-3-one in plasma reflect rates of bile acid synthesis in man. FEBS Lett. 239(2), 324-328 (1988).