An inhibitor of α-synuclein-induced toxicity
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Product Type

Biochemicals

Research Area

Neuroscience

NAB 2

Item No. 26145

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide
CAS Number
1504588-00-4
Molecular Formula
C23H20ClN3O
Formula Weight
389.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mL
λmax
220 nm
SMILES
ClC1=C(CNC(C2=CC=C(N(C3=C(C)C=CC(C)=C3)C=N4)C4=C2)=O)C=CC=C1
InChi Code
InChI=1S/C23H20ClN3O/c1-15-7-8-16(2)22(11-15)27-14-26-20-12-17(9-10-21(20)27)23(28)25-13-18-5-3-4-6-19(18)24/h3-12,14H,13H2,1-2H3,(H,25,28)
InChi Key
CZSLEMCYYGEGKP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $103

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    5 mg

    $178

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    10 mg

    $253

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    Product Description

    NAB 2 is an inhibitor of α-synuclein-induced toxicity.1 It prevents α-synuclein-induced defects in Rsp5-dependent endocytosis and vacuolar delivery of Mup1, Golgi-to-vacuole trafficking of Sna3, and degradation of Bap2 in wild-type yeast cells. NAB 2 also prevents formation of α-synuclein foci in wild-type yeast cells, an effect that is prevented by the rsp5G747E point mutation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tardiff, D.F., Jui, N.T., Khurana, V., et al. Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 342(6161), 979-983 (2013).