A precursor in the synthesis of PROTACs
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TC-E3 5032

Item No. 26147

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2,6-dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione
CAS Number
835616-60-9
Molecular Formula
C13H9FN2O4
Formula Weight
276.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/ml
λmax
214, 232, 240, 301 nm
SMILES
O=C(C1=C2C=CC=C1F)N(C3C(NC(CC3)=O)=O)C2=O
InChi Code
InChI=1S/C13H9FN2O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5H2,(H,15,17,18)
InChi Key
CRAUTELYXAAAPW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $117

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    100 mg

    $151

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    250 mg

    $257

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    500 mg

    $288

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    Product Description

    TC-E3 5032 is a precursor in the synthesis of homodimeric proteolysis-targeting chimera technologies (PROTACs).1 It has been used to attach various linkers at position 4 to produce alkylated pomalidomide derivatives as intermediates in the synthesis of homodimeric PROTACs. It has also been used as an intermediate in the synthesis of HDAC6 and anaplastic lymphoma kinase (ALK) degraders.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Steinebach, C., Lindner, S., Udeshi, N.D., et al. Homo-PROTACs for the chemical knockdown of cereblon. ACS Chem. Biol. 13(9), 2771-2782 (2018).

    2. Yang, K., Song, Y., Xie, H., et al. Development of the first small molecule histone deacetylase 6 (HDAC6) degraders. Bioorg. Med. Chem. Lett. 28(14), 2493-2497 (2018).

    3. Powell, C.E., Gao, Y., Tan, L., et al. Chemically induced degradation of anaplastic lymphoma kinase (ALK). J. Med. Chem. 61(9), 4249-4255 (2018).