A PROTAC precursor
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VH 032 Linker 1

Item No. 26148

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4R)-N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, monohydrochloride
CAS Number
2097971-11-2
Molecular Formula
C30H45N5O7S • HCl
Formula Weight
656.2
Purity
≥95%
Formulation (Request formulation change)
A solid
λmax
272 nm
SMILES
O=C([C@@H](NC(COCCOCCOCCN)=O)C(C)(C)C)N1C[C@H](O)C[C@H]1C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O.Cl
InChi Code
InChI=1S/C30H45N5O7S.ClH/c1-20-26(43-19-33-20)22-7-5-21(6-8-22)16-32-28(38)24-15-23(36)17-35(24)29(39)27(30(2,3)4)34-25(37)18-42-14-13-41-12-11-40-10-9-31;/h5-8,19,23-24,27,36H,9-18,31H2,1-4H3,(H,32,38)(H,34,37);1H/t23-,24+,27-;/m1./s1
InChi Key
ZOYHUTRHKHRRPK-QVRKWNSCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    25 mg

    $219

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    50 mg

    $350

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    100 mg

    $569

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    Cayman Chemical
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    Product Description

    VH 032 linker 1 is a precursor in the synthesis of the proteolysis-targeting chimeras (PROTACs) that contain a terminal amine conjugated via a PEG linker to VHL ligand 1 (Item No. 21591), which binds to VHL E3 ligase. It has been used in the synthesis of PROTACs targeting TEA domain transcription factors (TEADs) in cancer cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zbeig, J.R., Villemure, E., Rudolph, J., et al. Therapeutic compounds and methods of use. (2021).