An inhibitor of XPO1
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Verdinexor

Item No. 26171

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid, 2-(2-pyridinyl)hydrazide
CAS Number
1392136-43-4
Synonyms
  • KPT-335
Molecular Formula
C18H12F6N6O
Formula Weight
442.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 88 mg/mlEthanol: 11 mg/ml
λmax
232, 273 nm
SMILES
O=C(NNC1=CC=CC=N1)/C=C\N2C=NC(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=N2
InChi Code
InChI=1S/C18H12F6N6O/c19-17(20,21)12-7-11(8-13(9-12)18(22,23)24)16-26-10-30(29-16)6-4-15(31)28-27-14-3-1-2-5-25-14/h1-10H,(H,25,27)(H,28,31)/b6-4-
InChi Key
OPAKEJZFFCECPN-XQRVVYSFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Verdinexor is a reversible inhibitor of Exportin I (XPO1/CRM1) with anticancer and antiviral activities.1,2,3 It inhibits the growth of OCI-Ly3, OCI-Ly10, and CLBL1 diffuse large B cell lymphoma (DLBCL) cells (IC50s = 2.1, 41.8, and 8.5 nM, respectively).1 Verdinexor inhibits XPO1/CRM1-mediated nuclear transport of respiratory syncytial virus (RSV) M protein when used at concentrations greater than 1 μM.2 It reduces RSV A2 replication (IC50 = 0.96 μM) without affecting viability of A549 cells (CC50 = >38 μM). In vivo, verdinexor (20 mg/kg) reduces virus shedding, pulmonary TNF-α, IL-6, MCP-1, and IFN-γ expression, and leukocyte infiltration into the bronchoalveolar space in a mouse model of influenza A viral infection.3 It also reduces viral burden in a ferret model of influenza A viral infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. London, C.A., Bernabe, L.F., Barnard, S., et al. Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: Results of a phase I study. PLoS One 9(2), e8758 (2014).

    2. Jorquera, P.A., Matthew, C., Pickens, J., et al. Verdinexor (KPT-335), a selective inhibitor of nuclear export, reduces RSV replication in vitro. J. Virol. 93(4), e01684-e01718 (2018).

    3. Perwitasari, O., Johnson, S., Yan, X., et al. Antiviral efficacy of verdinexor in vivo in two animal models of influenza A virus infection. PLoS One 11(11), e0167221 (2016).