An inhibitor of p75NTR- and NRAGE-induced apoptosis
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AEG 3482

Item No. 26213

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide
CAS Number
63735-71-7
Molecular Formula
C10H8N4O2S2
Formula Weight
280.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 17 mg/mlDMSO: 17 mg/mlEthanol: 0.2 mg/ml
λmax
258 nm
SMILES
NS(C1=NN2C(S1)=NC(C3=CC=CC=C3)=C2)(=O)=O
InChi Code
InChI=1S/C10H8N4O2S2/c11-18(15,16)10-13-14-6-8(12-9(14)17-10)7-4-2-1-3-5-7/h1-6H,(H2,11,15,16)
InChi Key
MQUYTXDAVCOCMX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $186

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    25 mg

    $420

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    Product Description

    AEG 3482 is an inhibitor of p75NTR- and NRAGE-induced apoptosis.1 It inhibits JNK signaling, caspase-3 cleavage, and cell death induced by the p75 neurotrophin receptor (p75NTR) or the p75NTR-interacting protein NRAGE in PC12rtTA cells in a concentration-dependent manner. AEG 3482 inhibits cell death induced by withdrawal of nerve growth factor (NGF) in rat SCG neurons (EC50 = ~20 μM). It also increases Hsp70 and Hsp25 levels in mouse embryonic fibroblasts (MEFs) in an HSF1-dependent manner and binds to recombinant Hsp90.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Salehi, A.H., Morris, S.J., Ho, W.C., et al. AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. Chem. Biol. 13(2), 213-223 (2006).