A prodrug from of tenofovir
Related Products
Active Metabolite(s)
13874Tenofovir
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GS-7340

Item No. 26214

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine, 1-methylethyl ester
CAS Number
379270-37-8
Synonyms
  • TAF
  • Tenofovir Alafenamide
Molecular Formula
C21H29N6O5P
Formula Weight
476.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
262, 320 nm
SMILES
C[C@H](CN1C=NC2=C1N=CN=C2N)OC[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O
InChi Code
InChI=1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1
InChi Key
LDEKQSIMHVQZJK-CAQYMETFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    GS-7340 is a prodrug form of the antiviral adenosine analog tenofovir (Item No. 13874).1 It reduces HIV-1 viral replication in MT-2 cells with an EC50 value of 5 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, W.A., He, G.X., Eisenberg, E., et al. Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue. Antimicrob. Agents Chemother. 49(5), 1898-1906 (2005).