An inhibitor of fungal protein synthesis
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Sordarin (sodium salt)

Item No. 26255

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,3aR,4S,4aR,7R,7aR,8aS)-8a-[[(6-deoxy-4-O-methyl-β-D-altropyranosyl)oxy]methyl]-4-formyl-4,4a,5,6,7,7a,8,8a-octahydro-7-methyl-3-(1-methylethyl)-1,4-methano-s-indacene-3a(1H)-carboxylic acid, monosodium salt
CAS Number
463356-00-5
Molecular Formula
C27H39O8 • Na
Formula Weight
514.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
C[C@H]1O[C@@H](OC[C@@]23[C@@](C(C(C)C)=C[C@@]3([H])C4)(C([O-])=O)[C@@]4(C=O)[C@@]5([H])[C@]([C@H](C)CC5)([H])C2)[C@@H](O)[C@H](O)[C@@H]1OC.[Na+]
InChi Code
InChI=1S/C27H40O8.Na/c1-13(2)19-8-16-9-25(11-28)18-7-6-14(3)17(18)10-26(16,27(19,25)24(31)32)12-34-23-21(30)20(29)22(33-5)15(4)35-23;/h8,11,13-18,20-23,29-30H,6-7,9-10,12H2,1-5H3,(H,31,32);/q;+1/p-1/t14-,15-,16+,17-,18-,20+,21+,22-,23-,25+,26+,27+;/m1./s1
InChi Key
ILUKWKGTAAZHDW-IGICPMPSSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    Sordarin is an inhibitor of fungal protein synthesis originally isolated from S. araneosa.1 It binds to elongation factor 2 (EF-2) in the presence of ribosomes and inhibits the uncoupled GTPase activity of equimolar mixtures of EF-2 and ribosomes from C. albicans (IC50 = 0.1 μM). Sordarin inhibits protein synthesis in cell-free lysates of C. albicans, C. glabrata, and C. neoformans (IC50s = 0.01, 0.2, and 0.06 μg/ml, respectively) but not in rabbit reticulocytes (IC50 = >100 μg/ml).2 It inhibits the growth of C. albicans (MIC = 8 μg/ml) but not C. glabrata or C. neoformans (MICs = >125 μg/ml).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Domínguez, J.M., Gómez-Lorenzo, M.G., and Martín, J.J. Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid. The Journal of Biological Chemisty 274(32), 22423-22427 (1999).

    2. Domínguez, J.M., Kelly, V.A., Kinsman, O.S., et al. Sordarins: A new class of antifungals with selective inhibition of the protein synthesis elongation cycle in yeasts. Antimicrob. Agents Chemother. 42(9), 2274-2278 (1998).