An internal standard for the quantification of acyclovir
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Unlabeled Version(s)
14160Acyclovir
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Acyclovir-d4

Item No. 26272

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-9-((2-hydroxyethoxy-1,1,2,2-d4)methyl)-1,9-dihydro-6H-purin-6-one
CAS Number
1185179-33-2
Synonyms
  • ACV-d4
Molecular Formula
C8H7D4N5O3
Formula Weight
229.2
Purity
≥99% deuterated forms (d0-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C1C2=C(N(COC([2H])([2H])C([2H])([2H])O)C=N2)N=C(N)N1
InChi Code
InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)/i1D2,2D2
InChi Key
MKUXAQIIEYXACX-LNLMKGTHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $351

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    Product Description

    Acyclovir-d4 is intended for use as an internal standard for the quantification of acyclovir (Item No. 14160) by GC- or LC-MS. Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).1 It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.2 Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balfour, H.H., Jr. Management of cytomegalovirus disease with antiviral drugs. Rev. Infect. Dis. 12(Suppl. 7), S849-S860 (1990).

    2. Bean, B. Antiviral therapy: Current concepts and practices. Clin. Microbiol. Rev. 5(2), 146-182 (1992).

    3. Ashton, R.J., Abbott, K.H., Smith, G.M., et al. Antiviral activity of famciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16. J. Antimicrob. Chemother. 34(2), 287-290 (1994).