An Analytical Reference Standard
Related Products
Research Tool(s)
19691Tolvaptan
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Tolvaptan

Item No. 26301

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • OPC 41061
Technical Information
Formal Name
N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-benzamide
CAS Number
150683-30-0
Molecular Formula
C26H25ClN2O3
Formula Weight
448.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 30 mg/mLDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mLEthanol: 12 mg/mL
λmax
270 nm
SMILES
CC1=C(C(NC2=CC(C)=C(C(N3C(C=CC(Cl)=C4)=C4C(O)CCC3)=O)C=C2)=O)C=CC=C1
InChi Code
InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
InChi Key
GYHCTFXIZSNGJT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $128

    Add
    Cayman Chemical
    Cayman Spectral Library

    Our free, searchable, GC-MS spectral database contains 70eV EI mass spectral data of 2,000+ of Cayman’s forensic drug standards.

    DOWNLOAD THE DATABASE
    Product Description

    Tolvaptan (Item No. 26301) is an analytical reference standard categorized as a diuretic.1 Formulations containing diuretics have been abused as performance-enhancing drugs and masking agents in sports doping.2,3 This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 19691).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kondo, K., Ogawa, H., Yamashita, H., et al. 7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl ]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): A potent, orally active nonpeptide arginine vasopressin V2 receptor antagonist. Bioorg. Med. Chem. 7(8), 1743-1754 (1999).

    2. Cadwallader, A.B., de la Torre, X., Tieri, A., et al. The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: Pharmacology, toxicology and analysis. Br. J. Pharmacol. 161(1), 1-16 (2010).

    3. Mazzarino, M., Buccilli, V., de la Torre, X., et al. Characterization of the phase I and phase II metabolic profile of tolvaptan by in vitro studies and liquid chromatography-mass spectrometry profiling: Relevance to doping control analysis. J. Pharm. Biomed. Anal. 145, 555-568 (2017).