An Analytical Reference Standard
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15987Metolazone
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Metolazone

Item No. 26304

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • SR 720-22
Technical Information
Formal Name
7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide
CAS Number
17560-51-9
Molecular Formula
C16H16ClN3O3S
Formula Weight
365.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 0.3 mg/ml
λmax
237 nm
SMILES
O=C1C2=C(C=C(Cl)C(S(N)(=O)=O)=C2)NC(C)N1C3=CC=CC=C3C
InChi Code
InChI=1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)
InChi Key
AQCHWTWZEMGIFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

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    Product Description

    Metolazone (Item No. 26304) is an analytical reference standard categorized as a diuretic.1,2 It has been detected as an adverse analytical finding (AAF) during anti-doping testing.3 This product is intended for use in analytical forensic applications. This product is also available as a general research tool (Item No. 15987).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cadwallader, A.B., de la Torre, X., Tieri, A., et al. The abuse of diuretics as performance-enhancing drugs and masking agents in sport doping: Pharmacology, toxicology and analysis. Br. J. Pharmacol. 161(1), 1-16 (2010).

    2. Temperini, C., Cecchi, A., Scozzafava, A., et al. Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorg. Med. Chem. Lett. 18(8), 2567-2573 (2008).

    3. Agency, W.A.-D. 2014 Anti-doping testing figures report. (2014).