An inhibitor of 5-LO
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Lipoxygenin

Item No. 26310

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′,4,6-trimethoxy-α-2-naphthalenyl-[3,3′-bipyridine]-5-methanol
CAS Number
2247911-68-6
Molecular Formula
C24H22N2O4
Formula Weight
402.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
225 nm
SMILES
OC(C1=C(OC)C(C2=CC=CN=C2OC)=CN=C1OC)C3=CC=C(C=CC=C4)C4=C3
InChi Code
InChI=1S/C24H22N2O4/c1-28-22-19(18-9-6-12-25-23(18)29-2)14-26-24(30-3)20(22)21(27)17-11-10-15-7-4-5-8-16(15)13-17/h4-14,21,27H,1-3H3
InChi Key
OSVNGDATIGOCLA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $130

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    10 mg

    $236

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    Product Description

    Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 5 µM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 (Item No. 22030).1 It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 µM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 µM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 (Item No. 13122).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brand, S., Roy, S., Schröder, P., et al. Combined proteomic and in silico target identification reveal a role for 5-lipoxygenase in developmental signaling pathways. Cell Chem. Biol. 25(9), 1095-1106 (2018).