A modulator of HBV capsid assembly
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JNJ-632

Item No. 26325

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-fluoro-3-methylphenyl)-3-[[[(3S)-tetrahydro-3-furanyl]amino]sulfonyl]-benzamide
CAS Number
1572510-42-9
Molecular Formula
C18H19FN2O4S
Formula Weight
378.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 50 mg/ml
SMILES
O=S(C1=CC=CC(C(NC2=CC=C(F)C(C)=C2)=O)=C1)(N[C@@H]3COCC3)=O
InChi Code
InChI=1S/C18H19FN2O4S/c1-12-9-14(5-6-17(12)19)20-18(22)13-3-2-4-16(10-13)26(23,24)21-15-7-8-25-11-15/h2-6,9-10,15,21H,7-8,11H2,1H3,(H,20,22)/t15-/m0/s1
InChi Key
JIZGLOVJKCSHTH-HNNXBMFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    JNJ-632 is a modulator of hepatitis B virus (HBV) capsid assembly.1,2 It reduces viral DNA load in HBV-infected HepG2.2.15 cells (EC50 = 121 nM) without affecting cell growth.2 It also reduces viral DNA load in primary human hepatocytes infected with the HBV genotypes Ae, Bj, C, and D (EC50s = 101, 240, 119, and 200 nM, respectively). JNJ-632 prevents formation of covalently closed circular DNA in HBV-infected primary human hepatocytes in a concentration-dependent manner when administered in combination with the HBV viral inoculum. In vivo, JNJ-632 (200 mg/kg per day) reduces plasma HBV DNA content in HBV-infected humanized mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vandyck, K., Rombouts, G., Stoops, B., et al. Synthesis and evaluation of N-phenyl-3-sulfamoyl-benzamide derivatives as capsid assembly modulators inhibiting hepatitis B virus (HBV). J. Med. Chem. 61(14), 6247-6260 (2018).

    2. Berke, J.M., Dehertogh, P., Vergauwen, K., et al. Capsid assembly modulators have a dual mechanism of action in primary human hepatocytes infected with hepatitis B virus. Antimicrob. Agents Chemother. 61(8), pii: e00560-00176 (2017).