An activator of Wnt/β-catenin signaling
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SKL2001

Item No. 26334

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(2-furanyl)-N-[3-(1H-imidazol-1-yl)propyl]-3-isoxazolecarboxamide
CAS Number
909089-13-0
Synonyms
  • Wnt Agonist II
Molecular Formula
C14H14N4O3
Formula Weight
286.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
247, 288 nm
SMILES
O=C(NCCCN1C=CN=C1)C2=NOC(C3=CC=CO3)=C2
InChi Code
InChI=1S/C14H14N4O3/c19-14(16-4-2-6-18-7-5-15-10-18)11-9-13(21-17-11)12-3-1-8-20-12/h1,3,5,7-10H,2,4,6H2,(H,16,19)
InChi Key
PQXINDBPUDNMPE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    100 mg

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    Cayman Chemical
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    Product Description

    SKL2001 is an activator of Wnt/β-catenin signaling.1,2 It increases β-catenin responsive transcription in a cell-based reporter assay in a concentration-dependent manner, increases β-catenin protein levels in HEK293 cells when used at concentrations of 10 and 30 μM, and disrupts the interaction between Axin and β-catenin.1 SKL2001 increases alkaline phosphatase (ALP) activity and mineralization in multipotent mesenchymal ST2 cells in a concentration-dependent manner, indicating increased osteoblastogenesis. SKL2001 (40 μM) reduces HCT116 and HT-29 spheroid growth and inhibits proliferation of HCT116 and HT-29 cells.2 It induces cell cycle arrest at the G0/G1 phase and increases E-cadherin and β-catenin protein levels in HCT116 cells when used at a concentration of 40 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gwak, J., Hwang, S.G., Park, H.S., et al. Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation. Cell Res. 22(1), 237-247 (2012).

    2. Ohashi, W., Yamamine, N., Imura, J., et al. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. Biochem. Biophys. Res. Commun. 493(3), 1342-1348 (2017).